Network Pharmacology and Experimental Validation Reveal Sishen Pill’s Efficacy in Treating NSAID-Induced Small Intestinal Ulcers
This study elucidates SSP's multi-target mechanism against NSAID-induced SIUs, emphasizing its role in suppressing inflammation, oxidative stress, and PI3K/AKT signaling. These findings provide a scientific foundation for SSP's clinical application and highlight its potential as a safe, effective alternative to conventional therapies.
Authors
- Fengting Zhu
- Jiangtao Zhou (ORCID: https://orcid.org/0009-0000-9645-5859)
- Hong Liang (ORCID: https://orcid.org/0000-0002-0579-8651)
- Leimin Sun (ORCID: https://orcid.org/0000-0001-7269-8258)
Institutions
- Sir Run Run Shaw Hospital (CN)
- The Fourth People's Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/dddt.s502193
- Citations
- 2
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 3.11