Novel Organotin Complexes with Losartan: Synthesis and Biological Activity
Novel organotin(IV) complexes based on losartan have been synthesized and characterized by 1H, 13C, 119Sn NMR, IR, ESI-MS and elemental analysis. The antiproliferative activity of the complexes was assessed in vitro against human cancer cells, while their cytotoxic effects were examined on primary rat skin fibroblasts. The compounds exhibited strong activity, significantly inducing apoptosis. Additionally, they effectively suppressed the spasmogenic effect induced by angiotensin II in isolated rat portal veins.
Authors
- D. S. Yakovlev (ORCID: https://orcid.org/0000-0001-8980-6016)
- Е. Р. Милаева (ORCID: https://orcid.org/0000-0002-5489-3866)
- Dmitrii M. Mazur (ORCID: https://orcid.org/0000-0002-9780-1490)
- Yulia A. Gracheva (ORCID: https://orcid.org/0000-0003-4201-3523)
- Т.А. Антоненко (ORCID: https://orcid.org/0009-0000-0148-8288)
- Н. А. Гурова (ORCID: https://orcid.org/0000-0002-0670-1444)
- M. S. Pshenichnikova (ORCID: https://orcid.org/0000-0002-2043-8283)
- А. А. Спасов (ORCID: https://orcid.org/0000-0002-7185-4826)
- Vitaly A. Roznyatovsky
- O. A. Raykova
- Raul I. Musaev
Institutions
- Volgograd State Medical University (RU)
- Lomonosov Moscow State University (RU)
Publication Details
- Journal
- Biochemistry (Moscow) Supplement Series B Biomedical Chemistry
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1134/s1990750824601334
- Citations
- 1
- Primary Topic
- Organometallic Compounds Synthesis and Characterization
- Type
- article
- Field-Weighted Citation Impact
- 0.25