Comprehensive sequencing profile and functional analysis of IsomiRs in human pancreatic islets and beta cells
This study provides the first comprehensive isomiR profiling in human islets and beta cells, revealing their substantial contribution to miRNA regulation. IsomiR-411-5p-Ext5p(+1) emerges as a distinct key modulator of insulin secretion and granule dynamics in beta cells. These findings highlight isomiRs as potential biomarkers and therapeutic targets for diabetes, warranting further exploration of their roles in beta cell biology.
Authors
- Claudiane Guay (ORCID: https://orcid.org/0000-0002-6478-8744)
- Laura Nigi (ORCID: https://orcid.org/0000-0002-6251-3069)
- Caterina Formichi (ORCID: https://orcid.org/0000-0001-7703-8216)
- Marco Bruttini (ORCID: https://orcid.org/0000-0003-1063-2522)
- Elena Aiello (ORCID: https://orcid.org/0000-0002-2054-4369)
- Romano Regazzi (ORCID: https://orcid.org/0000-0002-9773-2915)
- E.A. Pedace (ORCID: https://orcid.org/0000-0002-0131-8534)
- Giuseppe Quero (ORCID: https://orcid.org/0000-0002-0001-9479)
- Gea Ciccarelli (ORCID: https://orcid.org/0009-0001-3621-6298)
- Giuseppina Emanuela Grieco (ORCID: https://orcid.org/0000-0001-7325-6128)
- Guido Sebastiani (ORCID: https://orcid.org/0000-0003-4374-8564)
- Daniela Fignani (ORCID: https://orcid.org/0000-0001-8803-5846)
- Gianfranco Di Giuseppe (ORCID: https://orcid.org/0000-0003-4506-5193)
- Laura Soldovieri (ORCID: https://orcid.org/0009-0001-3315-0406)
- Giada Licata (ORCID: https://orcid.org/0000-0001-6995-8581)
- Francesco Dotta (ORCID: https://orcid.org/0000-0003-4947-7478)
- Stefano Auddino (ORCID: https://orcid.org/0000-0002-7919-5597)
- Teresa Mezza (ORCID: https://orcid.org/0000-0001-5407-9576)
- Vincenzo Tondolo (ORCID: https://orcid.org/0000-0003-0256-3766)
- Agnese Pò (ORCID: https://orcid.org/0000-0002-9346-8782)
- Andrea Giaccari (ORCID: https://orcid.org/0000-0002-7462-7792)
- Andrea F. Berteramo
- Andrea Mari (ORCID: https://orcid.org/0000-0002-1436-5591)
- Alessia Mori (ORCID: https://orcid.org/0009-0002-3344-2772)
Institutions
- University of Siena (IT)
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
- Fatebenefratelli Hospital (IT)
- Precision for Medicine (United States) (US)
- Fondazione Umberto Di Mario (IT)
- National Research Council (IT)
- International Flame Research Foundation (IT)
- Sapienza University of Rome (IT)
- University of Lausanne (CH)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1007/s00125-025-06397-4
- Citations
- 2
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Università degli Studi di Siena