<sup>68</sup>Ga-Labeled Peptide for Noninvasive Quantifying Tumor Exposure of PD-L1 Therapeutics
[<sup>68</sup>Ga]HF12 was successfully synthesized as a radiotracer for noninvasive quantitative PET imaging of PD-L1 expression levels. This radiotracer exhibited the potential to quantify PD-L1 expression across various tumors, thereby facilitating the prediction of patient response to anti-PD-1 and anti-PD-L1 immunotherapies and monitoring therapeutic efficacy.
Authors
- Renbo Wu
- Lei Peng (ORCID: https://orcid.org/0000-0002-1206-2327)
- Dake Zhang (ORCID: https://orcid.org/0000-0001-9508-8209)
- Chengde Xie
- Tianhong Yang
- Xiangsong Zhang (ORCID: https://orcid.org/0000-0002-1730-9923)
- Hui Nie (ORCID: https://orcid.org/0000-0002-0447-8138)
- Zhihao Zha (ORCID: https://orcid.org/0009-0000-5360-3962)
- Lingyu Xue
- Junyu Chen (ORCID: https://orcid.org/0000-0001-9916-4395)
Institutions
- North China Electric Power University (CN)
- Sun Yat-sen University (CN)
- First People's Hospital of Foshan (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1021/acsomega.4c11396
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Key Technologies Research and Development Program of Guangzhou