Exploring the interplay between adipokine-mediated celastrol target genes and T cells in diabetic nephropathy: a mendelian randomization-based causal inference
Our findings reveal that celastrol modulates DN progression through adipokine-immune crosstalk, with FGF9, MAGI2, and THBS2 emerging as key regulatory genes. These insights provide new avenues for biomarker discovery and therapeutic implications in the development of DN.
Authors
- Xiaojuan Wang (ORCID: https://orcid.org/0000-0002-4235-9404)
- Khairul Anuar Shariff (ORCID: https://orcid.org/0000-0003-3331-2505)
- Mohd Asyraf Kassim (ORCID: https://orcid.org/0000-0002-4742-9993)
- Mohamad Hafizi Abu Bakar (ORCID: https://orcid.org/0000-0001-8064-695X)
- Jing Wang (ORCID: https://orcid.org/0000-0002-0449-8884)
- Manli Xu
Institutions
- Universiti Sains Malaysia (MY)
- Taizhou Vocational and Technical College (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s13098-025-01665-0
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00