Gastroesophageal reflux disease as a risk factor for oral cavity and pharyngeal cancer: a Mendelian randomization study
Our study showed that GERD significantly increased the overall risk of OCPC, and similar results were found for its subtype OCC. This causal effect appears to be independent of cigarette use, drinking habits, BMI, and T2D. However, evidence for a causal effect of GERD on OPC is limited, and further research is expected to extend this finding. Future studies should explore the specific biological mechanisms through which GERD increases OCPC risk.
Authors
- Zixiong Shen (ORCID: https://orcid.org/0009-0003-0436-7758)
- Chuanlei Wang (ORCID: https://orcid.org/0009-0005-7450-3561)
- Guangyi Wang (ORCID: https://orcid.org/0000-0003-1710-2196)
- Zhiqin Li (ORCID: https://orcid.org/0000-0001-8512-1925)
- Chun‐Li Cao
Institutions
- Nanchang University (CN)
- Jilin University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- First Hospital of Jilin University (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1007/s12672-025-02105-1
- Citations
- 3
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.43