Fibroblast IRF7-mediated chondrocyte apoptosis affects the progression of collapse in steroid-induced osteonecrosis of the femoral head
IRF7, HOOK1, RNPC3, KCNA3, CD48, and SAMD9 as potential genes affecting the progression of SIONFH collapse. Irf7 mediates the fibroblast inflammatory response and affects the collapse process of SIONFH by influencing chondrocyte apoptosis. Thus, intervention in IRF7 holds promise as one of the key targets for reversing the collapse process of SIONFH.
Authors
- Han Mingli
- Longfei Han (ORCID: https://orcid.org/0000-0003-4909-4960)
- Qiushi Wei (ORCID: https://orcid.org/0000-0002-1274-9997)
- Weihua Fang (ORCID: https://orcid.org/0000-0002-5621-6535)
- He Mincong
- Zhuang Zhikun
Institutions
- Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s13018-025-05557-x
- Citations
- 2
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.44
Funders
- National Natural Science Foundation of China