Deciphering the transcriptomic landscape of systemic lupus erythematosus-associated pulmonary arterial hypertension
Our investigation establishes inflammation as a key driver in the development of SLE-PAH. Patients who presented with concurrent dysregulations in inflammatory responses along with PAH-specific pathogenic markers exhibited a marked increase in the severity of their PAH. The insights gleaned from our transcriptomic analysis reveal the intricate interplay between inflammatory mechanisms and the molecular substrates of PAH. This nuanced understanding paves the way for more targeted and effective therapeutic approaches for SLE-PAH.
Authors
- Junyan Qian (ORCID: https://orcid.org/0000-0002-6909-539X)
- Xinzhuang Yang (ORCID: https://orcid.org/0000-0001-8345-9519)
- Zhuang Tian (ORCID: https://orcid.org/0000-0003-1140-4062)
- Jiuliang Zhao (ORCID: https://orcid.org/0000-0001-9308-2858)
- Mengtao Li (ORCID: https://orcid.org/0000-0003-4252-2889)
- Qizhi Yuan (ORCID: https://orcid.org/0009-0001-6097-6844)
- Xiaofeng Zeng (ORCID: https://orcid.org/0000-0002-3883-2318)
- Xiaoyue Deng (ORCID: https://orcid.org/0000-0002-0323-5070)
- Leyao Ma (ORCID: https://orcid.org/0009-0003-4512-0700)
- Qian Wang (ORCID: https://orcid.org/0000-0002-4541-9898)
- Yutong Li (ORCID: https://orcid.org/0000-0003-1141-2214)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12931-025-03169-x
- Citations
- 2
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China
- Peking Union Medical College Hospital
- Beijing Municipal Science and Technology Commission
- Beijing Nova Program