CAR-NK cell therapy combined with checkpoint inhibition induces an NKT cell response in glioblastoma
The combination therapy reverted the immunosuppressive tumor microenvironment with increased T and NKT cell infiltration. This resulted in successful treatment of advanced orthotopic tumors refractory to CAR-NK cell monotherapy.
Authors
- Iris Mildenberger (ORCID: https://orcid.org/0009-0008-8825-4908)
- G Ludmirski
- Michael C. Burger (ORCID: https://orcid.org/0000-0002-6927-0987)
- F Straßheimer
- Andreas Weigert (ORCID: https://orcid.org/0000-0002-7529-1952)
- Melanie Demes
- Jadranka Macas (ORCID: https://orcid.org/0000-0002-1661-2525)
- Torsten Tonn (ORCID: https://orcid.org/0000-0001-9580-2193)
- Winfried S. Wels (ORCID: https://orcid.org/0000-0001-9858-3643)
- Klaus‐Josef Weber
- Pınar Çakmak (ORCID: https://orcid.org/0000-0003-4652-6748)
- Joachim P. Steinbach (ORCID: https://orcid.org/0000-0002-4695-2483)
- Harald Krenzlin (ORCID: https://orcid.org/0000-0002-9001-8006)
- Yvonne Reiss (ORCID: https://orcid.org/0000-0002-6753-7502)
- P Elleringmann
- Blerina Aliraj (ORCID: https://orcid.org/0009-0003-1553-7687)
- Karl H. Plate
- Bastian Roller
- Tijna Alekseeva
Institutions
- Goethe University Frankfurt (DE)
- Goethe-Institute United Kingdom (GB)
- German Cancer Research Center (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- German Red Cross (DE)
- University Hospital Heidelberg (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- University Hospital Frankfurt (DE)
- Georg Speyer Haus (DE)
- University Medical Centre Mannheim (DE)
- Frankfurt Cancer Institute (DE)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1038/s41416-025-02977-8
- Citations
- 12
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 12.54