Genetically-determined variation in CRP impacts disease activity assessment in rheumatoid arthritis
The rs1205 TT genotype in CRP is associated with lower CRP and DAS28(CRP). Given the widespread use of CRP, this demonstrates that genetic factors, irrespective of an individual patient's disease activity, can cause differences in CRP that impact disease activity assessment.
Authors
- Katherine D. Wysham (ORCID: https://orcid.org/0000-0001-8707-7649)
- Michael March (ORCID: https://orcid.org/0000-0001-9173-6862)
- Austin M. Wheeler (ORCID: https://orcid.org/0000-0002-8816-7782)
- Kaleb D. Michaud (ORCID: https://orcid.org/0000-0002-5350-3934)
- Joshua F. Baker (ORCID: https://orcid.org/0000-0003-0799-7563)
- Michael George (ORCID: https://orcid.org/0000-0002-0398-2308)
- Brian C. Sauer (ORCID: https://orcid.org/0000-0002-3546-3051)
- Anurag Verma (ORCID: https://orcid.org/0000-0002-2460-9967)
- Scott M. Damrauer (ORCID: https://orcid.org/0000-0001-8009-1632)
- Kristin Wipfler (ORCID: https://orcid.org/0000-0001-8137-8117)
- Ted R. Mikuls (ORCID: https://orcid.org/0000-0002-0897-2272)
- Bryant R. England (ORCID: https://orcid.org/0000-0002-9649-3588)
- Grant W. Cannon (ORCID: https://orcid.org/0000-0001-6640-9173)
- Thomas R. Riley (ORCID: https://orcid.org/0009-0003-0194-7562)
Institutions
- Children's Hospital of Philadelphia (US)
- University of Washington (US)
- University of Utah (US)
- VA Puget Sound Health Care System (US)
- The National Databank for Rheumatic Diseases (US)
- Philadelphia VA Medical Center (US)
- VA Nebraska Western Iowa Health Care System (US)
- University of Nebraska Medical Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1093/rheumatology/keaf069
- Citations
- 3
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 5.00