Astrocytes Control Cocaine-Induced Synaptic Plasticity and Reward Through the Matricellular Protein Hevin
These findings reveal a fine-tuning by cocaine of in vivo Ca<sup>2+</sup> signals in NAc astrocytes. Astrocyte Ca<sup>2+</sup> signals are sufficient and necessary for the acquisition of cocaine-seeking behavior. Hevin can be released upon astrocyte activation and is a major effector of the action of cocaine and Ca<sup>2+</sup> signals on reward and neuronal plasticity.
Authors
- Amaia M. Erdozain (ORCID: https://orcid.org/0000-0003-0207-9122)
- Augusto Anésio (ORCID: https://orcid.org/0000-0002-6148-6855)
- Gustavo J. D. Fernandes
- Alfred J. Robison (ORCID: https://orcid.org/0000-0002-4150-9570)
- Sophie Gautron (ORCID: https://orcid.org/0000-0002-4510-7640)
- Franck Louis
- Antony A. Boucard (ORCID: https://orcid.org/0000-0002-5538-0464)
- Raphaële Mongrédien
- Andrew L. Eagle (ORCID: https://orcid.org/0000-0002-7879-5996)
- Clara Franco (ORCID: https://orcid.org/0000-0003-4927-3846)
- Vincent Vialou (ORCID: https://orcid.org/0000-0002-8212-751X)
- Carole Gruszczynski
- Steeve Maldera
- Catalina Betancur (ORCID: https://orcid.org/0000-0002-3327-4804)
- Nicolas Heck (ORCID: https://orcid.org/0000-0002-5754-8873)
- Marie-laure Niepon
- Adèle Vilette
- Dongdong Li (ORCID: https://orcid.org/0000-0002-6731-4771)
- Cuong Viet Pham (ORCID: https://orcid.org/0000-0001-6106-6685)
- Fabio Cardoso Cruz (ORCID: https://orcid.org/0000-0003-3765-7148)
- Paula Bianchi (ORCID: https://orcid.org/0000-0002-0532-8879)
- F R Bezerra
- Stéphane Robert
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- University of the Basque Country (ES)
- Sorbonne Université (FR)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Institut de Biologie Paris-Seine (FR)
- Neurosciences Paris-Seine (FR)
- Instituto Politécnico Nacional (MX)
- Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
- Michigan State University (US)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1016/j.biopsych.2025.02.904
- Citations
- 8
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.74
Funders
- National Alliance for Research on Schizophrenia and Depression
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Consejo Nacional de Ciencia y Tecnología
- Centre National de la Recherche Scientifique
- Sorbonne Université
- FP7 People: Marie-Curie Actions