MEOX1-mediated transcriptional regulation of circABHD3 exacerbates hepatic fibrosis through promoting m6A/YTHDF2-dependent YPEL3 mRNA decay to activate β-catenin signaling
MEOX1-mediated generation of circABHD3 promotes EMT and mitochondrial impairment by enhancing YTHDF2-mediated degradation of YPEL3 mRNA and activating downstream β-catenin signaling, thus exacerbating hepatic fibrosis.
Authors
- Kangkang Fu
- Haoye Zhang (ORCID: https://orcid.org/0009-0005-8324-5269)
- Zhenguo Liu (ORCID: https://orcid.org/0000-0003-2696-6535)
- Hui Yang (ORCID: https://orcid.org/0000-0002-9138-1325)
- Juan Wang (ORCID: https://orcid.org/0000-0003-1309-9444)
- Limin Chen (ORCID: https://orcid.org/0000-0001-5228-3522)
- Yu Yan (ORCID: https://orcid.org/0000-0003-4048-0603)
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- PLoS Genetics
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1371/journal.pgen.1011622
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China