A Computable Electronic Health Record ARDS Classifier and the Association Between the MUC5B Promoter Polymorphism and ARDS in Critically Ill Adults
The <i>MUC5B</i> promoter polymorphism was associated with EHR-ARDS in 2 parallel cohorts of at-risk adults. An age-gene effect modification was observed in VALID, whereas BioVU identified a consistent association between <i>MUC5B</i> and EHR-ARDS regardless of age. Our study highlights the potential for EHR biobanks to enable precision medicine ARDS studies.
Authors
- Lorraine B. Ware (ORCID: https://orcid.org/0000-0002-9429-4702)
- QiPing Feng (ORCID: https://orcid.org/0000-0002-6213-793X)
- Vern Eric Kerchberger (ORCID: https://orcid.org/0000-0002-0342-1965)
- J. Brennan McNeil (ORCID: https://orcid.org/0000-0002-9200-1881)
- Wei-Qi Wei (ORCID: https://orcid.org/0000-0003-4985-056X)
- Neil S. Zheng (ORCID: https://orcid.org/0000-0001-8737-0773)
- Julie A. Bastarache (ORCID: https://orcid.org/0000-0003-0458-6507)
- Carrie M. Rosenberger
- Diana Chang (ORCID: https://orcid.org/0000-0002-0832-7177)
- Angela J. Rogers (ORCID: https://orcid.org/0000-0001-6969-6200)
Institutions
- Vanderbilt University (US)
Publication Details
- Journal
- CHEST Critical Care
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1016/j.chstcc.2025.100150
- Citations
- 1
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Heart, Lung, and Blood Institute
- National Center for Advancing Translational Sciences