Patient-centric analysis of Orientia tsutsugamushi spatial diversity patterns across Hainan Island, China
These findings emphasize the urgent need for targeted public health interventions, particularly focusing on vulnerable populations in rural and agricultural areas of nine key administrative regions where high genetic diversity and pathogen spread were observed. Additionally, this study provides valuable insights into the transmission dynamics and infection progression of scrub typhus, using gene flow analysis and multilocus sequence typing to identify major sub-genotypes.
Authors
- Xiaoyuan Hu (ORCID: https://orcid.org/0009-0007-8233-1143)
- Jiang Du
- Fahui Wang (ORCID: https://orcid.org/0000-0001-7765-3024)
- Long Sun (ORCID: https://orcid.org/0000-0003-4889-4624)
- Liying Xue
- Feifei Yin (ORCID: https://orcid.org/0000-0001-6195-0614)
- Jasper Fuk‐Woo Chan (ORCID: https://orcid.org/0000-0001-6336-6657)
- Yike Guo (ORCID: https://orcid.org/0000-0002-3075-2161)
- Gaoyu Wang (ORCID: https://orcid.org/0000-0002-6423-2914)
- Yi Huang
- Chuanning Tang (ORCID: https://orcid.org/0000-0001-5413-6470)
- Kwok‐Yung Yuen (ORCID: https://orcid.org/0000-0002-2083-1552)
- Ruoyan Peng
- Yongguo Du
- Liyuan Zhang (ORCID: https://orcid.org/0000-0001-8041-0621)
- Siqi Chen (ORCID: https://orcid.org/0000-0001-8852-4850)
- Yi Niu (ORCID: https://orcid.org/0000-0002-8089-5582)
- Yueping Wang (ORCID: https://orcid.org/0009-0000-8902-5789)
- Wanxin Deng
- Jinyan Yang
- Biao Wu
- Nan Ge
- Yibo Jia (ORCID: https://orcid.org/0000-0003-2940-4300)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Hainan General Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Hainan Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1371/journal.pntd.0012909
- Citations
- 2
- Primary Topic
- Vector-borne infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.10
Funders
- National Natural Science Foundation of China