Mathematical and Numerical Modeling of the Pluripotency Gene Network Dynamics

We consider nonlinear dynamical systems as models of interaction of components of a gene network which regulates early stages of an embryonic stem cells state. A parametric analysis of these dynamical systems is performed in order to describe the (non)uniqueness and stability of their equilibriums. We have obtained a criterion of existence of periodic trajectories near these points and localized such oscillations on the phase portraits of dynamical systems which describe these processes. A special software for cloud numerical experiments with such systems has been elaborated.

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Publication Details

Journal
Numerical Analysis and Applications
Published
2025-03-01
DOI
https://doi.org/10.1134/s1995423925010033
Primary Topic
Gene Regulatory Network Analysis
Type
article
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article

Mathematical and Numerical Modeling of the Pluripotency Gene Network Dynamics

V. P. Golubyatnikov, E. A. Tatarinova
Numerical Analysis and Applications
Gene Regulatory Network Analysis
article

Mathematical and Numerical Modeling of the Pluripotency Gene Network Dynamics

V. P. Golubyatnikov, E. A. Tatarinova
article en

Abstract

We consider nonlinear dynamical systems as models of interaction of components of a gene network which regulates early stages of an embryonic stem cells state. A parametric analysis of these dynamical systems is performed in order to describe the (non)uniqueness and stability of their equilibriums. We have obtained a criterion of existence of periodic trajectories near these points and localized such oscillations on the phase portraits of dynamical systems which describe these processes. A special software for cloud numerical experiments with such systems has been elaborated.

Numerical Analysis and ApplicationsVol. 18(1)
Novosibirsk State University (RU)
Zero hunger
Openalex Percentile: Top 95%
Gene Regulatory Network Analysis
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