Targeting PI3K-mTOR signaling in the anterior cingulate cortex improves emotional behavior, and locomotor activity in rats with bone cancer pain
Targeting the PI3K-mTOR signaling pathway in the ACC effectively alleviates pain-related symptoms and emotional disturbances in rats with bone cancer pain. This approach holds promise for alleviating pain and allaying negative emotion after further study.
Authors
- Zongming Jiang (ORCID: https://orcid.org/0000-0002-7187-0842)
- Renzhong Zhu
- Yonghao Chen (ORCID: https://orcid.org/0000-0002-5736-7271)
- Fei Wang (ORCID: https://orcid.org/0000-0003-4066-287X)
- Yuan Zhang (ORCID: https://orcid.org/0000-0002-4630-0450)
- Shuyun Liu (ORCID: https://orcid.org/0009-0003-3047-9112)
- Qiliang Song
Institutions
- Shaoxing University (CN)
- Weatherford College (US)
- Shaoxing People's Hospital (CN)
- Shanghai Center For Bioinformation Technology (CN)
Publication Details
- Journal
- Annals of Medicine and Surgery
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1097/ms9.0000000000003206
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00