Investigation of alloimmunization in beta-thalassemia major patients: a cross-sectional study

The most prevalent unexpected antibodies were anti-K and anti-D, respectively, and anti-C, anti-E, and anti-jkb had the same frequencies. Fortunately, the frequency of unexpected antibodies in the BTM patients was lower compared to some other regions of Iran. One of the reasons for the relatively low amount of alloimmunization in the present study compared to the previous studies from Iran may be due to using regular leukoreduced packed cell unit consumption for the BTM patients. However, the continuation of antibody screening programs and the use of blood negative for the relevant antigen can increase the lifespan of the transfused cells in the patients.