The immunogenic potential of an optimized mRNA lipid nanoparticle formulation carrying sequences from virus and protozoan antigens
Altogether, these results indicate that these novel LNP-mRNA formulations are highly immunogenic and may be used as novel vaccine candidates for different infectious diseases.
Authors
- Bianca de Oliveira (ORCID: https://orcid.org/0000-0001-6572-4147)
- Juliana de Oliveira Silva (ORCID: https://orcid.org/0000-0002-6489-8935)
- Sarah Aparecida Rodrigues Sérgio (ORCID: https://orcid.org/0000-0002-6101-660X)
- Natália Satchiko Hojo-Souza (ORCID: https://orcid.org/0000-0002-3308-5149)
- Santuza Maria Ribeiro Teixeira (ORCID: https://orcid.org/0000-0002-2588-2842)
- Flávio Guimarães da Fonseca (ORCID: https://orcid.org/0000-0002-1416-8694)
- Milton Pereira (ORCID: https://orcid.org/0000-0003-2977-1565)
- Ricardo T. Gazzinelli (ORCID: https://orcid.org/0000-0003-2427-7699)
- Diêgo S. Ferreira (ORCID: https://orcid.org/0000-0003-1505-7950)
- Renata S. Fernandes (ORCID: https://orcid.org/0000-0003-0991-1292)
- Ana Paula Fernandes (ORCID: https://orcid.org/0000-0001-7085-4202)
- Nathalia Pereira Leite
- Gabriela de Assis Burle-Caldas
- Ana Flávia Bráz
Institutions
- Universidade Federal de Minas Gerais (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12951-025-03201-8
- Citations
- 9
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- University of Pennsylvania
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Centro Nacional de Pesquisa em Energia e Materiais
- Laboratório Nacional de Nanotecnologia