Inhibition of neutrophil extracellular traps alleviates blood–brain barrier disruption and cognitive dysfunction via Wnt3/β-catenin/TCF4 signaling in sepsis-associated encephalopathy
Our results suggest that inhibition of NETs may protect BBB permeability and cognitive function through the Wnt3/β-catenin/TCF4 signaling pathway in the context of CLP-induced SAE, which provides a promising strategy for SAE therapy.
Authors
- Lijuan Mo (ORCID: https://orcid.org/0000-0003-1204-437X)
- Yuhang Peng (ORCID: https://orcid.org/0000-0002-0549-6223)
- Yuan Cheng (ORCID: https://orcid.org/0000-0002-4476-7241)
- Jianhe Yue
- Xiang Zhang (ORCID: https://orcid.org/0000-0002-9900-3329)
- Guofen Zeng (ORCID: https://orcid.org/0009-0000-4275-6269)
- You Zhou (ORCID: https://orcid.org/0000-0002-7081-921X)
- Ping Ma (ORCID: https://orcid.org/0009-0003-7246-3143)
- Yongxiang Jiang (ORCID: https://orcid.org/0000-0001-9770-5733)
- Xiaolin Zhang (ORCID: https://orcid.org/0000-0003-0403-1560)
- Ning Huang (ORCID: https://orcid.org/0000-0001-5709-0666)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12974-025-03395-6
- Citations
- 23
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 18.34
Funders
- China Postdoctoral Science Foundation
- Chunhui Project Foundation of the Education Department of China