Intraoral myxoid fibrolipoma with chondroid areas: Diversified differentiation or a mere coincidence?

Background: Oral mesenchymal tumors are uncommon lesions, presenting as slow-growing exophytic masses. Myxofibrolipoma (MFL) is a lipoma variant comprising mature fat cells admixed with variable quantities of mucinous and fibrous stroma. Case Presentation: We present a case of a 15-year-old female presenting with swelling on the inner side of her left cheek, which she had noted for two weeks. With clinical differential diagnoses of mucocele, fibroma, and granuloma, the swelling was excised. Histopathological examination revealed it to be MFL with chondroid foci. Considering the site of the lesion and the absence of morphological signs of injury or irritation, labeling the chondroid foci as ‘metaplastic’ seemed doubtful in our case. Conclusion: The presented case highlights the plausible capacity of mesenchymal tumor cells in lipoma variants to exhibit divergent differentiation and reaffirms the importance of having a standardized nomenclature.