Neolignan and 3‐Benzylchroman Derivatives From <i>Celastrus orbiculatus</i> Thunb.
Phytochemical investigation of the ethyl acetate extract of the stems of Celastrus orbiculatus Thunb. led to the isolation of a new neolignan, celastorbiol A (1), and two new homoisoflavones, celastrones A and B (2 and 3), along with five known 3-benzylchroman derivatives, including 7,4'-dihydrohomoisoflavanone (4), 3-deoxysappanone B (5), 3'-deoxysappanone A (6), bonducelin (7), and sappanone A (8). Their structures were determined based on extensive spectroscopic and spectrometric data analyses, and computational studies. Compounds 1, 6, and 8 exhibited cytotoxic activities against human gastric cancer AGS and HGC-27 cell lines with IC<sub>50</sub> values that ranged from 42.82 ± 0.98 to 98.04 ± 1.33 µM.
Authors
- Dongdong Wang (ORCID: https://orcid.org/0000-0002-7824-2507)
- Shucheng Hua (ORCID: https://orcid.org/0000-0002-0083-3542)
- Li Miao (ORCID: https://orcid.org/0000-0003-3750-9612)
- Likui Zhang (ORCID: https://orcid.org/0000-0002-4662-1107)
- Haibo Wang (ORCID: https://orcid.org/0000-0002-7549-5613)
- Yanqing Liu (ORCID: https://orcid.org/0000-0001-6812-2811)
- Ping Liu (ORCID: https://orcid.org/0000-0002-3689-8364)
- Wei Jiang (ORCID: https://orcid.org/0000-0003-1067-0406)
Institutions
- Target (United States) (US)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
- Yangzhou University (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1002/cbdv.202500273
- Citations
- 1
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.38
Funders
- National Natural Science Foundation of China