Comparative profiling of surgically resected primary tumors and their lymph node metastases in small-cell lung cancer
Although the molecular landscape of SCLC LN metastases largely resembles that of the tumor of origin, key differences exist in terms of DLL3 and NEUROD1 expression, and in subtype distribution. These diagnostic pitfalls should be considered when establishing the tumors' molecular profile for future clinical trials solely based on LN biopsies.
Authors
- Kristóf Csende
- Katalin Dezső (ORCID: https://orcid.org/0000-0002-4856-0483)
- Anna Solta (ORCID: https://orcid.org/0000-0002-5164-010X)
- C. Lang
- K. Schelch
- Valeria Skopelidou (ORCID: https://orcid.org/0000-0001-7466-7535)
- Bence Ferencz (ORCID: https://orcid.org/0000-0001-9820-2441)
- Orsolya Pipek (ORCID: https://orcid.org/0000-0001-8109-0340)
- Balázs Döme (ORCID: https://orcid.org/0000-0001-8799-8624)
- Büsra Ernhofer (ORCID: https://orcid.org/0009-0008-2409-6402)
- Alex Ferenczy
- János Fillinger (ORCID: https://orcid.org/0000-0003-1877-8702)
- Zoltán Lohinai (ORCID: https://orcid.org/0000-0002-6442-9530)
- F. Renyi-Vamos
- Z. Megyesfalvi
- Jozef Škarda (ORCID: https://orcid.org/0000-0003-3579-3066)
- Viktória László (ORCID: https://orcid.org/0000-0002-6567-3965)
- L. Horváth (ORCID: https://orcid.org/0009-0008-7646-756X)
- A. Lantos
- Veronika Pozonec
- Clemens Aigner (ORCID: https://orcid.org/0000-0002-7787-991X)
- Kristiina Boettiger (ORCID: https://orcid.org/0009-0001-0602-5597)
- Evelyn Megyesfalvi (ORCID: https://orcid.org/0000-0002-1690-2450)
- Maria Dorothea Pozonec (ORCID: https://orcid.org/0009-0000-3802-4946)
Institutions
- Semmelweis University (HU)
- Eötvös Loránd University (HU)
- University of Ostrava (CZ)
- University Hospital Ostrava (CZ)
- Comprehensive Cancer Center Vienna (AT)
- Institute of Materials and Environmental Chemistry (HU)
- HUN-REN Institute of Experimental Medicine (HU)
- National Institute of Oncology (HU)
- Országos Korányi Tbc és Pulmonológiai Intézet (HU)
- Palacký University Olomouc (CZ)
- Medical University of Vienna (AT)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1016/j.esmoop.2025.104514
- Citations
- 2
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Semmelweis Egyetem
- Austrian Science Fund
- Magyar Tudományos Akadémia
- Innovációs és Technológiai Minisztérium
- Magyar Tüdőgyógyász Társaság