Shengui Sansheng San alleviates the worsening of blood–brain barrier integrity resulted from delayed tPA administration through VIP/VIPR1 pathway
SSS alleviates the worsening of BBB integrity resulted from delayed tPA administration, reduces hemorrhagic transformation and infarction volume, and ameliorates brain blood flow and neurological function in AIS mice. The mechanisms are associated with the activation of VIP/VIPR1 pathway to enhance BMECs viability and maintain tight junction phenotype.
Authors
- Xingping Quan
- Ruibing Wang (ORCID: https://orcid.org/0000-0001-9489-4241)
- Jinxia Hu (ORCID: https://orcid.org/0009-0009-4906-8114)
- E. Yu
- Yonghua Zhao (ORCID: https://orcid.org/0000-0001-8714-0476)
- Mengchen Yuan (ORCID: https://orcid.org/0000-0003-2896-0751)
- Minerva H Zhou (ORCID: https://orcid.org/0000-0003-2420-6970)
- Dawei Wang (ORCID: https://orcid.org/0000-0002-6651-4261)
- Yan Han (ORCID: https://orcid.org/0009-0003-5200-7757)
- Yiyang Li (ORCID: https://orcid.org/0000-0002-5791-9371)
- Jiahao Zhou (ORCID: https://orcid.org/0009-0002-3462-6442)
- Ying Chen (ORCID: https://orcid.org/0000-0002-8197-3108)
- Jinfen Chen
Institutions
- Nanjing University of Chinese Medicine (CN)
- Chinese University of Hong Kong (HK)
- University of Macau (MO)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Shenzhen Technology University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s13020-025-01079-0
- Citations
- 4
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- National Natural Science Foundation of China