FOXL2 drives the differentiation of supporting gonadal cells in early ovarian development
These findings suggest that FOXL2 facilitates the exit of differentiating cells from the coelomic epithelium and initially drives them towards a transitional identity before progressing into early supporting gonadal-like cells. The findings of this study significantly advance our understanding of normal gonadal development which can be used as a basis to elucidate pathological gonadal development underlying BPES.
Authors
- Juha S. Tapanainen (ORCID: https://orcid.org/0000-0002-3139-9128)
- Laura Danti
- Timo Tuuri (ORCID: https://orcid.org/0000-0003-0734-3244)
- Karolina Lundin (ORCID: https://orcid.org/0000-0003-1679-5349)
- Petra Nedeczey-Ruzsák
Institutions
- University of Helsinki (FI)
- University of Fribourg (CH)
- Helsinki University Hospital (FI)
- Karolinska Institutet (SE)
- Integrated Cardio Metabolic Centre (SE)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12958-025-01377-0
- Citations
- 3
- Primary Topic
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Helsingin Yliopisto