Single-Cell Expression Analysis of Ductal Carcinoma <i>In Situ</i> Identifies Complex Genotypic–Phenotypic Relationships Altering Epithelial Composition
Single-cell analyses reveal ductal carcinoma in situ comprises multiple genetic clones with significant phenotypic diversity and link alterations in epithelial cell states and basement membrane integrity with invasive breast cancer progression.
Authors
- Rachel E. Factor
- Xiaodi Qin (ORCID: https://orcid.org/0000-0001-7066-8151)
- Aashrith Saraswathibhatla (ORCID: https://orcid.org/0000-0002-0971-8065)
- Ovijit Chaudhuri (ORCID: https://orcid.org/0000-0002-9287-3401)
- E. Shelley Hwang (ORCID: https://orcid.org/0000-0002-8571-1148)
- Lunden Simpson (ORCID: https://orcid.org/0000-0002-7556-1078)
- Marissa R. Lee (ORCID: https://orcid.org/0000-0001-7188-9933)
- Kouros Owzar (ORCID: https://orcid.org/0000-0002-3340-1287)
- Graham A. Colditz (ORCID: https://orcid.org/0000-0002-7307-0291)
- Jeffrey R. Marks (ORCID: https://orcid.org/0000-0002-2054-5468)
- Lorraine King (ORCID: https://orcid.org/0009-0004-4617-7458)
- Robert B. West (ORCID: https://orcid.org/0000-0002-8330-8283)
- Shu Jiang (ORCID: https://orcid.org/0000-0003-1464-4838)
- Chunfang Zhu (ORCID: https://orcid.org/0000-0002-6773-0820)
- Sujay Vennam (ORCID: https://orcid.org/0000-0001-6312-1238)
- Xiaoke Luo (ORCID: https://orcid.org/0009-0006-8028-3822)
- Sushama Varma (ORCID: https://orcid.org/0000-0001-8137-0641)
- Siri H. Strand (ORCID: https://orcid.org/0000-0001-6596-9945)
- David G.P. van IJzendoorn (ORCID: https://orcid.org/0000-0002-2249-5919)
- Allison Hall (ORCID: https://orcid.org/0000-0003-3413-603X)
Institutions
- North Carolina State University (US)
- Duke University (US)
- Washington University in St. Louis (US)
- Duke Medical Center (US)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3023
- Citations
- 5
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 4.03