STAT1-mediated interferon signatures are associated with preclinical JAK inhibitor sensitivity in T-ALL
We used single-cell genomics to characterize a patient with T-cell acute lymphoblastic leukemia treated in the Children's Oncology Group AALL0434 trial with poor clinical outcome despite favorable genomic features, identifying a STAT1-mediated interferon-related transcriptional signature and inflammatory microenvironment associated with sensitivity to small-molecule JAK inhibition.
Authors
- Gregory M. Chen (ORCID: https://orcid.org/0000-0002-4083-5083)
- Kai Tan (ORCID: https://orcid.org/0000-0002-9104-5567)
- Mignon L. Loh (ORCID: https://orcid.org/0000-0003-4099-4700)
- Jason Xu (ORCID: https://orcid.org/0000-0002-9061-3593)
- Brent Lee Wood (ORCID: https://orcid.org/0000-0001-7414-3969)
- Jianzhong Hu (ORCID: https://orcid.org/0000-0002-7548-5802)
- Adam Barsouk (ORCID: https://orcid.org/0000-0003-2333-7530)
- Stephen P. Hunger (ORCID: https://orcid.org/0000-0002-5492-3957)
- Elizabeth A. Raetz (ORCID: https://orcid.org/0000-0002-8547-1658)
- David T. Teachey (ORCID: https://orcid.org/0000-0001-7373-8987)
- Petri Pölönen (ORCID: https://orcid.org/0000-0001-6128-9985)
- Austin Yang
- Mark Y. Chiang (ORCID: https://orcid.org/0000-0003-2099-0956)
- Haley Newman (ORCID: https://orcid.org/0000-0002-3022-8052)
- Alexander Li (ORCID: https://orcid.org/0009-0003-9852-0855)
- Stuart C. Winter (ORCID: https://orcid.org/0000-0002-8152-816X)
- Changya Chen (ORCID: https://orcid.org/0000-0003-4421-2462)
- Charles Grenfell Mullighan (ORCID: https://orcid.org/0000-0002-1871-1850)
- Satoshi Yoshimura (ORCID: https://orcid.org/0000-0003-3490-2101)
- David Wei Wu (ORCID: https://orcid.org/0000-0001-6197-7091)
- Yusha Sun (ORCID: https://orcid.org/0000-0003-4835-3000)
- Kimberly P. Dunsmore (ORCID: https://orcid.org/0000-0002-6631-5174)
- Shovik Bandyopadhyay (ORCID: https://orcid.org/0000-0003-3919-3914)
- Stanley Pounds (ORCID: https://orcid.org/0000-0002-9167-2114)
- Caroline Diorio (ORCID: https://orcid.org/0000-0002-8005-3836)
- Omar Elghawy (ORCID: https://orcid.org/0000-0002-0786-8035)
- Elizabeth Y Li (ORCID: https://orcid.org/0000-0001-9501-2263)
- Sharon Wald
- Danika Di Giacomo (ORCID: https://orcid.org/0000-0002-5558-7967)
- Kathrin M. Bernt (ORCID: https://orcid.org/0000-0002-0691-356X)
- Chia-Hui Chen (ORCID: https://orcid.org/0000-0001-5239-1574)
- Meenakshi Devidas (ORCID: https://orcid.org/0000-0002-1099-3478)
- Tristan Lim (ORCID: https://orcid.org/0000-0002-3798-5400)
- Jonathan Sussman (ORCID: https://orcid.org/0000-0002-3057-3550)
- Jun J Yang
- Tiffaney L. Vincent
- Damjan Karanfilovski
Institutions
- Seattle Children's Hospital (US)
- St. Jude Children's Research Hospital (US)
- Children’s Minnesota - St. Paul Hospital (US)
- Children's Hospital of Philadelphia (US)
- Children's Hospital of Los Angeles (US)
- University of Washington (US)
- University of Perugia (IT)
- University of Michigan (US)
- University of Virginia Health System (US)
- Yale University (US)
- NYU Langone Health (US)
- University of Virginia Children's Hospital (US)
- Seattle Children's Hospital (US)
- Michigan United (US)
- Michigan Medicine (US)
- Children's Minnesota (US)
- University of Virginia (US)
- New York University (US)
- University of Pennsylvania (US)
- Philadelphia University (US)
Publication Details
- Journal
- Blood
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1182/blood.2025028566
- Citations
- 1
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77