Improving effects of melatonin on memory and synaptic potentiation in a mouse model of Alzheimer’s-like disease: the involvement of glutamate homeostasis and mGluRs receptors
These findings underscore the neuroprotective properties of melatonin, mediated by its ability to modulate glutamate signaling and mGluR activity, offering new insights into its potential as a therapeutic agent for AD. Additionally, the results suggest that earlier administration of melatonin may significantly enhance its efficacy, highlighting the importance of timely intervention in neurodegenerative diseases.
Authors
- Koorosh Shahpasand (ORCID: https://orcid.org/0000-0003-2153-0564)
- Narjes Khatoun Shabani Sadr (ORCID: https://orcid.org/0000-0003-0682-8856)
- Fatemeh Bakhtiarzadeh (ORCID: https://orcid.org/0000-0002-2969-8145)
- Mehrdad Behmanesh (ORCID: https://orcid.org/0000-0002-3901-304X)
- Javad Mirnajafi-Zadeh
Institutions
- Tarbiat Modares University (IR)
- Royan Institute (IR)
- Academic Center for Education, Culture and Research (IR)
Publication Details
- Journal
- Behavioral and Brain Functions
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12993-025-00271-4
- Citations
- 6
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 5.49
Funders
- Cognitive Sciences and Technologies Council
- Tarbiat Modares University