Enhancing myelinogenesis through LIN28A rescues impaired cognition in PWMI mice
Our study reveals that LIN28A is critical in regulating postnatal myelinogenesis. Overexpression of LIN28A in OPCs rescues cognitive deficits in PWMI mice by promoting myelinogenesis, thus providing a potential strategy for the treatment of PWMI.
Authors
- Zuo Luan (ORCID: https://orcid.org/0000-0003-2703-9741)
- Yinxiang Yang (ORCID: https://orcid.org/0000-0002-2935-6751)
- Huimin Yue (ORCID: https://orcid.org/0000-0002-4992-4998)
- Xuan Wu (ORCID: https://orcid.org/0000-0001-8539-6611)
- Ying Shen (ORCID: https://orcid.org/0000-0001-7034-5328)
- Chao Wang (ORCID: https://orcid.org/0000-0003-2412-406X)
- Jie Li (ORCID: https://orcid.org/0000-0001-5856-6312)
- Liang Wang (ORCID: https://orcid.org/0000-0001-6047-5284)
- Zhechun Hu
- Yan Gu
Institutions
- Allen Institute for Brain Science (US)
- Sir Run Run Shaw Hospital (CN)
- Chinese PLA General Hospital (CN)
- Zhejiang Lab (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s13287-025-04267-9
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Natural Science Foundation of China
- China National Funds for Distinguished Young Scientists
- National Key Research and Development Program of China