Extracellular vesicles derived from mesenchymal stem cells alleviate renal fibrosis via the miR-99b-5p/mTOR/autophagy axis in diabetic kidney disease
hP-MSC-derived EVs can mitigate renal injury in DKD by modulating the miR-99b-5p/mTOR/autophagy pathway. These findings suggest a potential cell-free therapeutic strategy for managing DKD.
Authors
- Xiaoniao Chen (ORCID: https://orcid.org/0000-0002-7620-4400)
- Rui Li (ORCID: https://orcid.org/0009-0001-9557-516X)
- Hongyan Tao
- Zongjin Li (ORCID: https://orcid.org/0000-0002-4603-3743)
- Kai Pan (ORCID: https://orcid.org/0009-0006-2871-6969)
- Zhikun Guo (ORCID: https://orcid.org/0000-0002-7627-5508)
- Rongrong Li (ORCID: https://orcid.org/0000-0003-3772-2309)
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- Zhengzhou People's Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s13287-025-04265-x
- Citations
- 11
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 8.87
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin Municipal Science and Technology Commission