Cellular sentinels: empowering survival and immune defense in hematopoietic stem cell transplantation through mesenchymal stem cells and T lymphocytes
Our study presents a novel therapeutic strategy combining allo-HSCs, activated T cells, and third-party MSCs to enhance neutrophil production and functionality post-transplantation. This approach not only accelerates neutrophil regeneration but also improves resistance to infections, offering a promising avenue to overcome engraftment challenges in HSCT.
Authors
- Yun‐Hsiang Chen (ORCID: https://orcid.org/0000-0002-2439-1080)
- Liwen Fang (ORCID: https://orcid.org/0000-0003-3406-358X)
- Yu-Shao Yang
- Chao‐Ling Yao (ORCID: https://orcid.org/0000-0002-7196-5833)
- Jiun-Han Lin
- Tzong-Shyuan Tai (ORCID: https://orcid.org/0000-0003-0575-914X)
- Shu‐Chen Kuo (ORCID: https://orcid.org/0000-0002-6940-6450)
- Jiaqi Shi (ORCID: https://orcid.org/0000-0002-8458-2364)
- Duen‐Wei Hsu (ORCID: https://orcid.org/0000-0001-5762-7806)
- Shu-Ching Hsu (ORCID: https://orcid.org/0000-0002-6244-2803)
Institutions
- Fu Jen Catholic University (TW)
- Ministry of Economic Affairs (TW)
- National Kaohsiung Normal University (TW)
- Kaohsiung Medical University (TW)
- National Chung Hsing University (TW)
- National Health Research Institutes (TW)
- China Medical University (TW)
- Tzu Chi University (TW)
- National Tsing Hua University (TW)
- Chang Gung Memorial Hospital (TW)
- Taoyuan Chang Gung Memorial Hospital (TW)
- Food Industry Research and Development Institute (TW)
- National Cheng Kung University (TW)
- I-Shou University (TW)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12916-025-03987-2
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Technology, Taiwan
- National Health Research Institutes
- National Science and Technology Council