Dynamic profiling of Cell-free DNA fragmentation uncovers postprandial metabolic and immune alterations
The fragmentation of cfDNA is considerably influenced by postprandial states, highlighting the significance of taking postprandial effects into account when evaluating cfDNA as a biomarker. Furthermore, our study reveals the potential application of cfDNA fragmentation features in monitoring metabolic and immune status changes.
Authors
- Manting Zhang
- Xiaodi Shi (ORCID: https://orcid.org/0009-0008-4062-4009)
- Zhihua Tao (ORCID: https://orcid.org/0000-0002-0906-7143)
- Ziting Zhu (ORCID: https://orcid.org/0000-0002-0662-205X)
- Xuchu Wang (ORCID: https://orcid.org/0000-0003-3137-4390)
- Tao Chen (ORCID: https://orcid.org/0000-0003-4368-808X)
- Xiuzhi Duan (ORCID: https://orcid.org/0000-0002-1577-0513)
- J Liu (ORCID: https://orcid.org/0000-0002-4509-0279)
- Pan Yu
Institutions
- Zhejiang Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Human Genomics
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s40246-025-00739-4
- Citations
- 8
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 7.49
Funders
- National Natural Science Foundation of China