Exploring the impact of gut microbiota-mediated regulation of exosomal miRNAs from bone marrow mesenchymal stem cells on the regulation of bone metabolism
These findings highlight the significant role of g_Ruminococcus in alleviating osteoporosis induced by estrogen deficiency, suggesting its therapeutic potential for addressing postmenopausal osteoporosis through the targeted modulation of BMSC-derived exosomal miR-151-3p and miR-23b-3p.
Authors
- Haiyan Xue (ORCID: https://orcid.org/0000-0001-5682-3573)
- Rudan Zhou (ORCID: https://orcid.org/0000-0002-8698-0120)
- Guannan Luo (ORCID: https://orcid.org/0000-0002-4584-6814)
- Xinpeng Guo (ORCID: https://orcid.org/0000-0002-1564-9406)
- Xiaoyu Fan (ORCID: https://orcid.org/0000-0002-0390-5871)
- Zhihua Wang (ORCID: https://orcid.org/0000-0002-0967-287X)
- Li Feng (ORCID: https://orcid.org/0000-0003-2898-8308)
- Xiujun Zhang (ORCID: https://orcid.org/0000-0003-0469-740X)
- Fan Yu (ORCID: https://orcid.org/0000-0002-4903-993X)
- Shen Xiang-lin (ORCID: https://orcid.org/0000-0002-2144-4490)
- Hongyu Zheng
- Bin He (ORCID: https://orcid.org/0000-0001-8468-7492)
Institutions
- North China University of Science and Technology (CN)
- Peking University (CN)
- Kunming Medical University (CN)
- China International Science and Technology Cooperation (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s13287-025-04256-y
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Kunming Medical University