RNA-binding protein SAMD4A targets FGF2 to regulate cardiomyocyte lineage specification from human embryonic stem cells
Our study demonstrates that SAMD4A orchestrates cardiomyocyte lineage commitment through the post-transcriptional regulation of FGF2 and modulation of AKT signaling. These findings not only underscore the essential role of SAMD4A in cardiac organogenesis, but also provide critical insights into the molecular mechanisms underlying heart development, thereby informing potential therapeutic strategies for congenital heart disease.
Authors
- Qin Lin (ORCID: https://orcid.org/0000-0002-7535-9451)
- Xiao Tao (ORCID: https://orcid.org/0000-0002-9381-7903)
- Han Cao (ORCID: https://orcid.org/0000-0003-3612-6169)
- Lin Fang (ORCID: https://orcid.org/0000-0002-9971-4569)
- Shanshan Hu (ORCID: https://orcid.org/0000-0003-4776-1977)
- Luying Peng (ORCID: https://orcid.org/0000-0002-0033-767X)
- Hongrong Wang (ORCID: https://orcid.org/0000-0002-4980-1082)
- Huan Liu (ORCID: https://orcid.org/0000-0001-8694-3736)
- Li Li (ORCID: https://orcid.org/0000-0003-0524-7515)
- Junfang Zhang (ORCID: https://orcid.org/0000-0001-5969-4789)
- Yuping Zhu
- Na Yi (ORCID: https://orcid.org/0000-0001-6005-093X)
- Yuanguang Meng (ORCID: https://orcid.org/0000-0003-3813-8411)
- Yongjin Sun (ORCID: https://orcid.org/0000-0002-0474-8556)
Institutions
- Tongji University (CN)
- Shanghai East Hospital (CN)
- Shanghai Zhabei District Shibei Hospital (CN)
- State Key Laboratory of Cardiovascular Disease
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s13287-025-04269-7
- Citations
- 1
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China