Extracellular vesicle-bound S100A8/A9 is differentially expressed in septic shock and prompts acute lung injury
Our results suggested that EV S100A8/A9 has potential value in distinguishing septic shock from sepsis and predicting the development of ARDS. Septic shock EVs-induced lung injury is at least partially mediated through S100A8/A9-RAGE pathway, involving the activation of alveolar macrophages.
Authors
- Qiang Shu (ORCID: https://orcid.org/0000-0002-4106-6255)
- Ruoqiong Huang
- Guoping Zheng (ORCID: https://orcid.org/0000-0002-5551-4522)
- Jie Xia (ORCID: https://orcid.org/0000-0003-4574-9376)
- Guanguan Qiu
- Weiliang Wu
- Zhenkai Le
- Ruoxi Zang
- Jiangmei Wang (ORCID: https://orcid.org/0009-0002-5678-5348)
- Tingting Wen (ORCID: https://orcid.org/0000-0002-3435-6959)
- Jianguo Xu (ORCID: https://orcid.org/0000-0002-5053-8525)
- Ruoyang Zhang
- Yaoqin Hu
- Huifeng Qian (ORCID: https://orcid.org/0009-0000-1110-5666)
Institutions
- Children's Hospital of Zhejiang University (CN)
- Shaoxing Second Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12931-025-03181-1
- Citations
- 5
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China
- Zhejiang University
- Health Commission of Zhejiang Province
- Basic Public Welfare Research Program of Zhejiang Province