Coronary cytoskeletal modulation of coronary blood flow in the presence and absence of type 2 diabetes: the role of cofilin
Together, we demonstrated that the CRM VSMC actin cytoskeleton is altered in T2DM to favor less stiff cells, and pharmacological manipulation of the actin cytoskeleton alters VSMC biomechanics. This study is also the first to demonstrate that coronary cellular modulation of mechanics can acutely modulate coronary blood flow.
Authors
- Patricia E. McCallinhart
- Pamela A. Lucchesi
- Aaron J. Trask (ORCID: https://orcid.org/0000-0003-2236-0659)
- K S Stone (ORCID: https://orcid.org/0009-0000-2911-5555)
Institutions
- Nationwide Children's Hospital (US)
- The University of Texas at Tyler (US)
- The Ohio State University (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-03-18
- DOI
- https://doi.org/10.3389/fphys.2025.1561867
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health