Radiation damage and recovery of plastic scintillators under ultra-high dose rate 200 MeV electrons at CERN CLEAR facility

<i>Objective.</i>The FLASH effect holds significant potential in improving radiotherapy treatment outcomes. Very high energy electrons (VHEEs) with energies in the range of 50-250 MeV can effectively target tumors deep in the body and can be accelerated to achieve ultra-high dose rates (UHDR), making them a promising modality for delivering FLASH radiotherapy in the clinic. However, apart from suitable VHEE sources, clinical translation requires accurate dosimetry, which is challenging due to the limitation of standard dosimeters under UHDR conditions. In this study, water-equivalent and real-time plastic scintillation dosimeters (PSDs) are tested to evaluate their viability for FLASH VHEE dosimetry.<i>Approach.</i>A 4-channel PSD, consisting of polystyrene-based BCF12 and Medscint proprietary scintillators, polyvinyltoluene-based EJ-212 and a blank plastic fiber channel for Cherenkov subtraction was exposed to the 200 MeV VHEE UHDR beam at the CLEAR CERN facility. The Hyperscint RP200 platform was used to assess linearity to dose pulses of up to 90 Gy and dose rates up to4.6×109Gy s<sup>-1</sup>, and to investigate radiation damage and recovery after dose accumulation of 37.2 kGy.<i>Main</i><i>results.</i>While blank fiber response was linear across the entire dose range studied, light output saturated above 45 Gy/pulse for scintillators. Despite radiation damage, linearity was preserved, though it resulted in a decrease of scintillator and blank fiber light output of<1.87%/kGy and a shift in spectra towards longer wavelengths. Short-term recovery (<100 h) of these changes was observed and depended on rest duration and accumulated dose. After long-term rest (<172 days), light output recovery was partial, with 6%-22% of residual permanent damage remaining, while spectral recovery was complete.<i>Significance.</i>We showed that PSDs are sensitive to radiation damage, but maintain dose linearity even after a total accumulated dose of 37.2 kGy, and exhibit significant response recovery. This work highlights the potential of PSDs for dosimetry in UHDR conditions.

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Publication Details

Journal
Physics in Medicine and Biology
Published
2025-03-18
DOI
https://doi.org/10.1088/1361-6560/adc234
Citations
4
Primary Topic
Radiation Therapy and Dosimetry
Type
article
Field-Weighted Citation Impact
6.07

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article

Radiation damage and recovery of plastic scintillators under ultra-high dose rate 200 MeV electrons at CERN CLEAR facility

Pierre Korysko, Magdalena Bazalova‐Carter, Alexander Hart, Joseph Bateman et al.
4 citations
Physics in Medicine and Biology
Radiation Therapy and Dosimetry
6.07
article

Radiation damage and recovery of plastic scintillators under ultra-high dose rate 200 MeV electrons at CERN CLEAR facility

Pierre Korysko, Magdalena Bazalova‐Carter, Alexander Hart, Joseph Bateman, Luc Beaulieu, Cloé Giguère, Yoan LeChasseur, Wilfrid Farabolini
article en
4 citations

Abstract

<i>Objective.</i>The FLASH effect holds significant potential in improving radiotherapy treatment outcomes. Very high energy electrons (VHEEs) with energies in the range of 50-250 MeV can effectively target tumors deep in the body and can be accelerated to achieve ultra-high dose rates (UHDR), making them a promising modality for delivering FLASH radiotherapy in the clinic. However, apart from suitable VHEE sources, clinical translation requires accurate dosimetry, which is challenging due to the limitation of standard dosimeters under UHDR conditions. In this study, water-equivalent and real-time plastic scintillation dosimeters (PSDs) are tested to evaluate their viability for FLASH VHEE dosimetry.<i>Approach.</i>A 4-channel PSD, consisting of polystyrene-based BCF12 and Medscint proprietary scintillators, polyvinyltoluene-based EJ-212 and a blank plastic fiber channel for Cherenkov subtraction was exposed to the 200 MeV VHEE UHDR beam at the CLEAR CERN facility. The Hyperscint RP200 platform was used to assess linearity to dose pulses of up to 90 Gy and dose rates up to4.6×109Gy s<sup>-1</sup>, and to investigate radiation damage and recovery after dose accumulation of 37.2 kGy.<i>Main</i><i>results.</i>While blank fiber response was linear across the entire dose range studied, light output saturated above 45 Gy/pulse for scintillators. Despite radiation damage, linearity was preserved, though it resulted in a decrease of scintillator and blank fiber light output of<1.87%/kGy and a shift in spectra towards longer wavelengths. Short-term recovery (<100 h) of these changes was observed and depended on rest duration and accumulated dose. After long-term rest (<172 days), light output recovery was partial, with 6%-22% of residual permanent damage remaining, while spectral recovery was complete.<i>Significance.</i>We showed that PSDs are sensitive to radiation damage, but maintain dose linearity even after a total accumulated dose of 37.2 kGy, and exhibit significant response recovery. This work highlights the potential of PSDs for dosimetry in UHDR conditions.

Physics in Medicine and BiologyVol. 70(7)
University of Victoria (CA), University of Oxford (GB), HES-SO Genève (CH), Québec Metro High Tech Park (Canada) (CA), Hôtel-Dieu de Québec (CA), Science Oxford (GB), Université Laval (CA), European Organization for Nuclear Research (CH)
Canada Research Chairs, Mitacs, Natural Sciences and Engineering Research Council of Canada
Affordable and clean energy
Openalex Percentile: Top 4%
Radiation Therapy and Dosimetry
6.07
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