Gasdermin E-mediated intestinal epithelial pyroptosis promotes chemically induced colitis in mice
We show that GSDME-mediated epithelial pyroptosis contributes to the development of DSS-induced colitis by promoting intestinal inflammation and disrupting the intestinal epithelial barrier.
Authors
- Yi-Zhong Wu
- Yao Xie (ORCID: https://orcid.org/0000-0003-4108-7037)
- Xiaoping Xu (ORCID: https://orcid.org/0000-0002-8934-1287)
- Lin Chen (ORCID: https://orcid.org/0000-0001-7764-9412)
- Lei Ning
- Xiaoqi Hu
Institutions
- University of South China (CN)
Publication Details
- Journal
- Gastroenterology report
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/gastro/goaf021
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Health Commission of Hunan Province