Impact of RAS, BRAF mutations and microsatellite status in peritoneal metastases from colorectal cancer treated with cytoreduction + HIPEC: scoping review
RAS and BRAF mutations correlate with poorer outcomes in PM-CRC, underscoring the need for mutation-informed strategies to refine HIPEC and systemic therapies. Recognizing subtypes may improve patient selection for CRS-HIPEC, optimizing both local disease control and long-term survival. Future research should incorporate these molecular profiles to enhance therapeutic decision-making and better address this challenging condition.
Authors
- Giorgio Ercolani (ORCID: https://orcid.org/0000-0003-4334-5167)
- Riccardo Turrini (ORCID: https://orcid.org/0000-0003-0133-7492)
- Daniela Di Pietrantonio (ORCID: https://orcid.org/0000-0002-1276-2382)
- Ilario Giovanni Rapposelli (ORCID: https://orcid.org/0000-0003-1802-5671)
- Fabrizio D’Acapito (ORCID: https://orcid.org/0000-0001-6420-6209)
- E. Pozzi (ORCID: https://orcid.org/0009-0007-0977-428X)
- Massimo Framarini
- Valentina Zucchini
Institutions
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Ospedale G.B. Morgagni - L.Pierantoni (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Bologna (IT)
Publication Details
- Journal
- International Journal of Hyperthermia
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1080/02656736.2025.2479527
- Citations
- 6
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 12.04