The pathogenesis of hepatocellular carcinoma: ERK/ULK1/NCOA4-mediated inhibition of iron autophagy, and Epimedium extract targeted modulation of this pathway to treat hepatocellular carcinoma
The ERK/ULK1/NCOA4-mediated iron autophagy inhibition represents a novel therapeutic mechanism for HCC. The clinical adjuvant drug EPME may exert therapeutic effects on HCC by activating ERK/ULK1/NCOA4-mediated iron autophagy.
Authors
- Xinxin Yang (ORCID: https://orcid.org/0000-0002-2024-4307)
- Xiansheng Meng (ORCID: https://orcid.org/0000-0003-2814-4615)
- Yongrui Bao (ORCID: https://orcid.org/0000-0003-0588-2113)
- Shuai Wang (ORCID: https://orcid.org/0000-0002-8895-5199)
- Tianjiao Li (ORCID: https://orcid.org/0009-0003-4719-6071)
- Xun Tian (ORCID: https://orcid.org/0000-0002-4602-7589)
- Liying Han (ORCID: https://orcid.org/0009-0000-4204-2303)
Institutions
- Liaoning University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1016/j.phymed.2025.156666
- Citations
- 5
- Primary Topic
- Medicinal Plant Pharmacodynamics Research
- Type
- article
- Field-Weighted Citation Impact
- 7.79