Targeted activation on Bnip3 enhances mitophagy to prevent the progression of osteoarthritis
As a classical drug in clinic, tiopronin was developed a new therapeutic approach in the treatment in OA via this study. Based the significant and efficient effect of tiopronin in inhibiting the cartilage degermation and delay the progression of OA, it was believed that tiopronin may become an effective therapeutic candidate for OA treatment in clinical settings.
Authors
- Lin Zheng (ORCID: https://orcid.org/0000-0002-9372-8281)
- Jiawei Li
- Chunde Bao
- Kejian Fu
- Xinchen Gu (ORCID: https://orcid.org/0000-0002-0563-2395)
- Baiting Chen
- Yiyuan Xu (ORCID: https://orcid.org/0000-0002-1296-358X)
- Qi Chen (ORCID: https://orcid.org/0000-0001-6353-9589)
- Xiang Zhang (ORCID: https://orcid.org/0000-0002-6416-558X)
- Man Zhang (ORCID: https://orcid.org/0000-0003-1174-3881)
- Enxing Xue
- Chenglong Xie (ORCID: https://orcid.org/0000-0003-3592-9058)
- Nan Hui
- Hangjin Zhou
- Yong Gou
- Shenkai Su
- Chenggui Wang
Institutions
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Zhejiang Mariculture Research Institute (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.jot.2025.01.012
- Citations
- 3
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.06