Ki-67 expression in anti-programmed cell death protein-1 antibody-bound CD8+ T cells as a predictor of clinical benefit
The expression of Ki-67 of PB-CD8<sup>+</sup> T<sub>CM</sub> and T<sub>EM</sub> can serve as a predictive biomarker for the clinical benefit of pembrolizumab therapy. Our study suggests that analyzing antibody-bound T cells could be a novel approach to predict the clinical outcomes of PD-1 blockade therapy.
Authors
- Takuya Tsunoda (ORCID: https://orcid.org/0000-0002-6416-8211)
- Toshiaki Tsurui (ORCID: https://orcid.org/0000-0002-6167-8953)
- Eiji Funayama
- Aya Sasaki
- Yutaro Kubota (ORCID: https://orcid.org/0000-0002-2917-8764)
- Kiyoshi Yoshimura (ORCID: https://orcid.org/0000-0003-4816-1826)
- Atsuo Kuramasu
- Midori Shida
- Junya Isobe
- Y Maruyama
- Yuta Baba (ORCID: https://orcid.org/0000-0002-5743-0306)
- Hirotsugu Ariizumi (ORCID: https://orcid.org/0000-0003-1663-8730)
- Yasunobu Amari
- Ryotaro Ohkuma (ORCID: https://orcid.org/0000-0003-4121-2491)
- Atsushi Horiike (ORCID: https://orcid.org/0000-0002-1632-3125)
- Mayumi Tsuji (ORCID: https://orcid.org/0000-0001-8005-9069)
- Hitoshi Toyoda
- Tomoyuki Ishiguro
- Masahiro Shimokawa (ORCID: https://orcid.org/0000-0002-8645-4112)
- Nana Iriguchi
- Masahiro Hosonuma (ORCID: https://orcid.org/0000-0002-5861-7543)
- Yuko Udaka
- Yuya Hirasawa
- Satoshi Wada (ORCID: https://orcid.org/0000-0003-1276-6620)
- Emiko Mura
- Yuji Kiuchi
- Kohei Tajima
- Risako Suzuki
- Yoshitaka Yamazaki
Institutions
- SHOWA Medical University (JP)
- Toho University (JP)
- Tokai University (JP)
- Toho University Ohashi Medical Center (JP)
- SHOWA Medical University Fujigaoka Hospital (JP)
- SHOWA Medical University Hospital (JP)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1007/s12672-025-02060-x
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09