Utility and cost-effectiveness of LiverMultiScan for MASLD diagnosis: a real-world multi-national randomised clinical trial
Adding mpMRI to SoC for the management of adults with suspected MASLD multi-nationally is cost-effective, enhances rate of diagnosis multi-nationally and increases rate of diagnosis without increasing other liver-related health care resource use. Due to the need for standardisation of SoC, widespread use can support optimisation of the MASLD clinical pathway and improve long-term patient management.
Authors
- Stephen T. Barclay (ORCID: https://orcid.org/0000-0003-0415-785X)
- Andrew Fraser (ORCID: https://orcid.org/0000-0001-9939-6014)
- Elizabeth Shumbayawonda (ORCID: https://orcid.org/0000-0003-0351-2063)
- Daniel Forton (ORCID: https://orcid.org/0000-0002-0903-9169)
- Saima Ajaz (ORCID: https://orcid.org/0000-0002-1089-1949)
- Janisha Patel (ORCID: https://orcid.org/0000-0002-4634-0751)
- Paula Lorgelly (ORCID: https://orcid.org/0000-0002-8990-9514)
- Cayden Beyer
- Michael H. Miller (ORCID: https://orcid.org/0000-0003-4389-0149)
- Jelte J. Schaapman (ORCID: https://orcid.org/0000-0003-0691-4818)
- Matthias Dollinger (ORCID: https://orcid.org/0000-0002-2742-2524)
- Jane Elizabeth Carolan (ORCID: https://orcid.org/0000-0002-1270-1774)
- Johanna Backhus (ORCID: https://orcid.org/0000-0002-4903-5840)
- Minneke J. Coenraad (ORCID: https://orcid.org/0000-0002-3434-4421)
- Rajarshi Banerjee (ORCID: https://orcid.org/0000-0003-2022-5218)
- Hildo J. Lamb (ORCID: https://orcid.org/0000-0002-6969-2418)
- Kosh Agarwal (ORCID: https://orcid.org/0000-0002-4754-828X)
- Daniel James Cuthbertson (ORCID: https://orcid.org/0000-0002-6128-0822)
- Marika French (ORCID: https://orcid.org/0000-0002-9296-8320)
- Dimitar Tonev (ORCID: https://orcid.org/0000-0003-0142-318X)
- Christopher D. Byrne (ORCID: https://orcid.org/0000-0001-6322-7753)
- Miguel Castelo‐Branco (ORCID: https://orcid.org/0000-0003-4364-6373)
Institutions
- St George's Hospital (GB)
- University of Liverpool (GB)
- St. Elizabeth Hospital in Enumclaw (US)
- Leiden University Medical Center (NL)
- Glasgow Royal Infirmary (GB)
- Southampton General Hospital (GB)
- Ninewells Hospital (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- King's College Hospital (GB)
- University Hospital Ulm (DE)
- Queen Elizabeth University Hospital (GB)
- University of Southampton (GB)
- University College London (GB)
- University of Coimbra (PT)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1038/s43856-025-00796-9
- Citations
- 13
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 17.60
Funders
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- National Institute for Health and Care Research
- European Commission
- Horizon 2020 Framework Programme