Clinical Value of Metagenomic Next-Generation Sequencing From Blood Samples to Identify <i>Pneumocystis jirovecii</i> Pneumonia in Patients With Human Immunodeficiency Virus
Our study indicates that mNGS of blood samples exhibits high sensitivity and specificity for diagnosing PJP in PWH. Caution should be exercised when interpreting low <i>Pj</i> mNGS read counts in blood samples; the definitive diagnosis of PJP relies on the synthesis of clinical data with <i>Pj</i> mNGS results. Further studies are necessary to validate this finding.
Authors
- Yan He (ORCID: https://orcid.org/0000-0002-4316-8298)
- Hongyu Luo (ORCID: https://orcid.org/0000-0003-3357-9154)
- Huaying Zhou
- Yongfang Jiang (ORCID: https://orcid.org/0000-0003-3880-0583)
Institutions
- Central South University (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1093/ofid/ofaf170
- Primary Topic
- Pneumocystis jirovecii pneumonia detection and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00