Integrated bioinformatics and validation reveal TMEM45A in systemic lupus erythematosus regulating atrial fibrosis in atrial fibrillation
The crosstalk genes underlying co-pathogenesis between SLE and AF were unraveled. Furthermore, the pro-fibrotic role of TMEM45A was validated in vivo and vitro, highlighting its potential as a therapeutic target for AF.
Authors
- Zhi-yun XU
- Ye Ma (ORCID: https://orcid.org/0000-0001-5818-7777)
- Xiaoping Ning
- Han Lin (ORCID: https://orcid.org/0000-0001-6222-8252)
- Sufan Ding
- Yi Shen (ORCID: https://orcid.org/0000-0002-7778-3125)
- Yu Qi (ORCID: https://orcid.org/0000-0002-6190-7349)
- XU Hong-jie
Institutions
- Second Military Medical University (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Changhai Hospital (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s10020-025-01162-0
- Citations
- 6
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 8.33
Funders
- National Natural Science Foundation of China
- Key Technologies Research and Development Program