LDH and hemoglobin outperform systemic inflammatory indices as prognostic factors in patients with soft tissue sarcoma undergoing neoadjuvant treatment
Pre-treatment LDH and hemoglobin are strong independent predictors of survival in HR-STS patients. Systemic inflammatory indices based on circulating immune cells may not serve as reliable prognostic factors for HR-STS patients undergoing curative-intent treatment. Higher pre-treatment albumin levels and lower CRP values may reflect a reduced inflammatory status and could be associated with a poorer radiologic response to preoperative treatment.
Authors
- Hans Roland Dürr (ORCID: https://orcid.org/0000-0002-1347-1173)
- Michael von Bergwelt‐Baildon (ORCID: https://orcid.org/0000-0002-1952-052X)
- Anton Burkhard‐Meier (ORCID: https://orcid.org/0009-0002-9801-3530)
- Luc M. Berclaz (ORCID: https://orcid.org/0000-0003-4405-138X)
- Alexander Klein (ORCID: https://orcid.org/0000-0002-5562-9872)
- Dorit Di Gioia
- Sina Mansoorian
- Vindi Jurinović
- Wolfgang G. Kunz (ORCID: https://orcid.org/0000-0002-5021-1952)
- Thomas Knösel (ORCID: https://orcid.org/0000-0002-1822-0197)
- Markus Albertsmeier (ORCID: https://orcid.org/0000-0002-5028-5062)
- Lars H. Lindner (ORCID: https://orcid.org/0000-0003-3708-8264)
- Sinan E Güler
- Michael Völkl
Institutions
- LMU Klinikum (DE)
- Zimmer Biomet (Germany) (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12885-025-13889-4
- Citations
- 5
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 5.23