Unraveling Survival Determinants in Patients with Advanced Non-Small-Cell Lung Cancer with EGFR Exon 20 Insertions

EGFR-TKIs may be considered as an alternative treatment option for patients with <i>EGFR</i> exon 20 insertions in cases where the currently recommended therapies, such as chemotherapy with or without amivantamab, are either unavailable or intolerable. The potential use of afatinib for specific patients in this context depends on the precise characteristics of their mutation and remains to be determined.

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Publication Details

Journal
Current Oncology
Published
2025-03-18
DOI
https://doi.org/10.3390/curroncol32030174
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
0.00
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article

Unraveling Survival Determinants in Patients with Advanced Non-Small-Cell Lung Cancer with EGFR Exon 20 Insertions

K. Wang, Yu‐Feng Wei, Jui-Chi Hung, Chung‐Yu Chen et al.
Current Oncology
Lung Cancer Treatments and Mutations
article

Unraveling Survival Determinants in Patients with Advanced Non-Small-Cell Lung Cancer with EGFR Exon 20 Insertions

K. Wang, Yu‐Feng Wei, Jui-Chi Hung, Chung‐Yu Chen, Cheng‐Yu Chang, Shih-Chieh Chang
article en

Abstract

EGFR-TKIs may be considered as an alternative treatment option for patients with <i>EGFR</i> exon 20 insertions in cases where the currently recommended therapies, such as chemotherapy with or without amivantamab, are either unavailable or intolerable. The potential use of afatinib for specific patients in this context depends on the precise characteristics of their mutation and remains to be determined.

Current OncologyVol. 32(3)
National Yang Ming Chiao Tung University (TW), Far Eastern Memorial Hospital (TW), National Taiwan University Hospital (TW), National Yunlin University of Science and Technology (TW), I-Shou University (TW), Yuan Ze University (TW)
Openalex Percentile: Top 92%
Lung Cancer Treatments and Mutations
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