167 Measuring neuropsychiatric symptoms in people with frontotemporal lobar degeneration using IPOS-Dem

<h3>Background</h3> Frontotemporal lobar degeneration (FTLD) is a rare, heterogeneous form of dementia that can affect younger people, in which neuropsychiatric symptoms (NPS) are common. The Integrated Palliative Outcome Scale for People with Dementia (IPOS-Dem) is a person-centred assessment of needs in dementia. We aimed to assess whether items measuring NPS in IPOS-Dem correlate with other measures of NPS in people with FTLD. <h3>Method</h3> IPOS-Dem, Neuropsychiatric Inventory (NPI) and medication history were completed for 26 people with moderate or severe FTLD. A summary score of 6 IPOS-Dem items measuring NPS was calculated. IPOS-Dem free-text responses recording participants’ concerning problems were coded for reference to NPS. Associations between IPOS-Dem NPS score, medication class and free-text responses were estimated. IPOS-Dem was conceptually mapped to NPI, and agreement on prevalence between instruments for shared symptoms measured. Mean scores for individual NPI items were calculated. We calculated correlation between IPOS-Dem NPS and NPI scores. Statistical tests were non-parametric. <h3>Results</h3> 15 (63%) participants prescribed psychoactive medications. In 12 (46%) participants NPS documented as a concerning problem, with 7 (27%) documenting symptoms not measured in IPOS-Dem. There was no evidence that IPOS-Dem NPS scores were associated with taking psychoactive medications (p=0.88) or documenting NPS as a concerning problem (p=0.37). NPI included 12 items, of which 6 were measured in IPOS-Dem items. The most burdensome symptoms in NPI (agitation, anxiety, depression and irritability) were measured by IPOS-Dem with agreement (p&lt;0.05) between instruments. Apathy was the most prevalent symptom on NPI (n=23) and was not measured in IPOS-Dem, with poor agreement with related IPOS-Dem item ‘Loss of interest’ (p=0.439). There was strong correlation between NPIQ and IPOS-Dem NPS scores (r=0.70;p&lt;0.001). <h3>Conclusions</h3> IPOS-Dem captured burdensome NPS in this study. Psychometric testing in larger FTLD populations would be beneficial to validate its use and assess other NPS not included in NPI.