Single-cell transcriptomic analysis reveals CD8 + T cell heterogeneity and identifies a prognostic signature in cervical cancer
Our study provides valuable insights into the heterogeneity and functional diversity of CD8 + T cells in CESC. We demonstrate that a CD8 + T cell-related prognostic signature may serve as a potential tool for risk stratification in patients with CESC. Additionally, our finding suggests that sorafenib could be a promising therapeutic candidate for improving antitumor immunity in this patient population.
Authors
- Wenhao Lu (ORCID: https://orcid.org/0000-0001-8660-2886)
- Yuli Xie
- Fubo Wang (ORCID: https://orcid.org/0000-0002-2209-9932)
- Zige Liu (ORCID: https://orcid.org/0000-0002-6659-3692)
- Zuheng Wang
- Rongbin Zhou (ORCID: https://orcid.org/0000-0002-3351-6420)
- Xiao Li (ORCID: https://orcid.org/0000-0002-6120-3800)
- Xing Li (ORCID: https://orcid.org/0000-0001-6469-4839)
- Chunmeng Wei (ORCID: https://orcid.org/0000-0002-7303-969X)
Institutions
- Guangxi Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Guangxi Zhuang Autonomous Region Health and Family Planning (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Shanghai First People's Hospital (CN)
- Tumor Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12885-025-13901-x
- Citations
- 10
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 10.45
Funders
- National Natural Science Foundation of China