Developing and validating a prognostic disulfidptosis-related signature for glioblastoma: predicting radioresistance and synergestic effect with immunotherapy
Our study bioinformatically and experimentally reveals the molecular landscape of disulfidptosis in GBM, develops a predictive signature for predicting prognosis as well as radioresistance, and provides a synergistic treatment that combines radiotherapy with immunotherapy for radioresistant GBM patients with high DRS or EFEMP2 expression.
Authors
- Wenqing Feng (ORCID: https://orcid.org/0000-0002-9683-3490)
- Peixin Tan
- Shushu Hu
- Yantan Liu
- Lei Yuan (ORCID: https://orcid.org/0000-0002-7516-2819)
- Chen Chen (ORCID: https://orcid.org/0000-0003-2104-534X)
- Chen Ren
- Shasha Du (ORCID: https://orcid.org/0000-0002-4810-7996)
- Dehuan Xie
Institutions
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1007/s00432-025-06159-0
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Natural Science Foundation of China