Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response
Because of their defective G1 checkpoint mechanisms, cancer cells often activate a G2 checkpoint, which leads to resistance to DNA-damaging chemotherapeutics. We identify an intercellular heterogeneity of SGs that is driven by the cell cycle, with SG formation being highest in the G2 phase. Targeting G2-specific SG formation sensitizes pancreatic tumors to G2 arrest-inducing chemotherapeutics.
Authors
- Guillaume Fonteneau (ORCID: https://orcid.org/0000-0002-7369-4360)
- Alexandra Redding (ORCID: https://orcid.org/0000-0002-2834-1398)
- Matthias M. Gaida (ORCID: https://orcid.org/0000-0003-1499-7772)
- Stefan Heinrich (ORCID: https://orcid.org/0000-0001-9961-0957)
- Elda Grabocka (ORCID: https://orcid.org/0000-0001-7196-8498)
Institutions
- Thomas Jefferson University (US)
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Sidney Kimmel Cancer Center (US)
- Klinikum Mutterhaus der Borromäerinnen (DE)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1144
- Citations
- 5
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 4.03